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Never had these problems, you've either only used lower end ones or the CX style or the SRT and not looked after them or ballsed up the installation etc.Twist grips/gripshifts require require quite a squeeze in order to overcome cable forces & the tightness within the mechs/cables. This is often why some people do not get on with them. In wet/cold conditions changing gear can be almost impossible. Wether she can cope with this or if it is fine with her condition - only she can answer that one. I would guess a thumbshifter offers the most versatility & the option to use it with the palm of the hand or more strength.
Newer Waveys are ace and not a problem, they also can have spring assist and have the extra wide diameter imboard if you're in snow, mud lard, etc. And really need it.
You mostly don't twist with a hand thumb/finger grip, but your hand, the half pipes make it a palm twist.
But as always it try it and see, it'll be attached to Tourney gears. Would be great to see what is tried.
Sturmey did a big thumb thufter, often used on trikes and disability bikes, horrible thing my son hated it.. May only work with hub hears.