Most of the knee knackering hoohaa came from the roadbike crowd who were using oval rings before biopace with the longitudonal axis not in line with the cranks. Old style road oval rings were to a degree worked out in shed engineering without much scientific application plus roadies turn bigger rings which of course put more strain on the knees. So when Shimano came out with Biopace the roadies just shouted out how crap oval rings were.
Shimano however did a great deal of scientific and engineering studies of mechanical efficiency and ergonomics. When the crank is at the high point you have the most potential power you can put down and when at horizontal the least. Thus when climbing up a hill on loose terrain when your power has dropped as the cranks become horizontal your effective gear drops aswell thus compensating for the power loss.
I think Shimano had thought it out well its just prejudgemental roadies shot it down before it had a proper chance to prove itself./quote]
Biopace are marvellous, they changed the phasing to reduce knee strain-
http://sheldonbrown.com/biopace.html -I have one leg shorter than the other, yes yes, I know everyone does but mine are more so and have suffered leg probs in the past after riding bikes with round rings. However when I'm on my Biopace SG equipped Marins I can outclimb most people and no problems.
If you are someone who has tried Biopace and it's damaged your legs check the alignment of the chainrings on the cranks to make sure some doofus former owner hasn't changed the phasing to "Improve" it.
Other manufacturers who made non-round chain rings with Biopace phasing were Sugino [Cycloid] and Sakae [Ovaltech].
Here are some Ofmega oval touring jobbies that I picked up but haven't had chance to tinker with yet. Although Ofmega weren't a Biopace licencee as far as I know they look to me like the phasing - if not the shape, which is too regular- is in the same plane as Biopace. What do you think?